You can find more detailed instructions on this here.
Ensure the game is running on your primary graphics card by navigating to Options from the game's main menu, selecting Visuals, and then under Video Settings, check that the Video Card Selection is set to your primary graphics card.Only PCs that far exceed the recommended specifications should run at Ultra settings. If your PC meets Dishonored 2's recommended requirements, we encourage you to play with your Video Settings set too High for a more consistent (60fps) experience.Here are some general tips to help improve performance: If you meet the game’s requirements, you can try the following troubleshooting steps:
If you are experiencing performance issues when trying to play Dishonored 2, you should first check to ensure that your machine meets the game’s minimum requirements here.